By an in vitro study, we evaluated whether curcumin could influence the proliferation, migration, and invasion activities of LUAD cells. Survival analysis and molecular docking were used to analyze the effectiveness of the hub genes. Functional enrichment analysis was conducted to further clarify its biological properties and hub genes were identified by a protein–protein interaction (PPI) network analysis. Materials and Methods: LUAD mRNA expression data were obtained from TCGA database and differentially expressed genes (DEGs) were identified using R software.
In the present study, we used comprehensive bioinformatics analysis and in vitro experiments to explore the anti-tumor mechanism of curcumin. Previous studies have demonstrated that curcumin has great potential as a therapeutic agent, but the lack of understanding of the functional mechanism of the drug has hindered the widespread use of the natural product. *These authors contributed equally to this workĬorrespondence: Hui-Jie Li Xiu-Rong Li, Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jingshi Road, Jinan, Shandong, 250014, People’s Republic of China, Email īackground: As the main component of turmeric ( Curcuma longa L.), curcumin is widely used in the treatment of various diseases. ↵ 4 Present address: University of California, San Diego, Department of Bioengineering, La Jolla, California 92093, USA.Fei-Ran Yang, 1, * Si-Yi Li, 1, * Xi-Wen Hu, 1 Xiu-Rong Li, 2 Hui-Jie Li 2ġCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China 2Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China Thus, plug-ins also provide a general means of introducing and testing new features. Several of Cytoscape's core features (graph layout and node attribute mapping) ultimately led us to incorporate it into theĬytoscape Core platform. ↵ 7 Although attribute-based layout was initially implemented as a plug-in, its general applicability and tight integration with To accommodate new biological problems-is gained by not inscribing the notion of specific biological entities directly into Node attributes entitled “expression ratio” or “cellular compartment.” In this way, great freedom and flexibility-the ability For example, the core may represent a node (an abstract conceptįree of biological semantics) whose label is GCN4 (a text string with significance to yeast biologists as an important transcription factor) or we might use the Core to define Of course, there is often substantialīiological significance associated with data in the Core. Problem by leaving it to plug-in writers to adopt semantics adequate to the problem at hand. Were in the Cytoscape Core, we would be faced with a difficult question which semantics should we use? Cytoscape avoids this ↵ 6 Biological semantics vary widely within the biological community as well as fromproject to project.
#Download cytoscape download#
[The Cytoscape v1.1 Core runs on all major operating systems and is freely available for download from Interaction network for Halobacterium, and an interface to detailed stochastic/kinetic gene regulatory models. SeveralĬase studies of Cytoscape plug-ins are surveyed, including a search for interaction pathways correlating with changes in geneĮxpression, a study of protein complexes involved in cellular recovery to DNA damage, inference of a combined physical/functional The Core is extensible throughĪ straightforward plug-in architecture, allowing rapid development of additional computational analyses and features.
#Download cytoscape software#
Cytoscape's software Core providesīasic functionality to layout and query the network to visually integrate the network with expression profiles, phenotypes,Īnd other molecular states and to link the network to databases of functional annotations. Although applicable to any system of molecular componentsĪnd interactions, Cytoscape is most powerful when used in conjunction with large databases of protein-protein, protein-DNA,Īnd genetic interactions that are increasingly available for humans and model organisms. Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expressionĭata and other molecular states into a unified conceptual framework.
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